Monday, May 28, 2012

The Hazards of Energy Efficient Light Bulbs and Proper Disposal Methods

Energy Efficient Light BulbsEnergy saving light bulbs are old news when it comes to the cutting edge developments in the home energy efficiency. Many homes utilize these bulbs that are much more efficient compared to ordinary bulbs when it comes to power consumption as they save Chicago homeowners on electricity bills.

However, there are safety and health concerns conceding energy saving light bulbs. WesTrac has issued a bulletin listing the dangers associated with low-energy bulbs. These possible health hazards include:

  • If a low-energy bulbs breaks, leave the room for at least 15 minutes because the bulbs contain mercury, which is poisonous and contributes to migraines, disorientation, imbalances and other health problems when inhaled.
  • By just touching a broken bulb, ?people with allergies, skin condition and other diseases can be strongly effected.
  • Refrain from cleaning broken bulb pieces with a vacuum cleaner as this will only spread the contamination to other rooms of your home when using the vacuum again.

The proper way to dispose of broken low-energy bulbs is to clean the pieces with a normal brush or broom, place the debris in a sealed bag and dispose of it right away in a hazardous material bin such as municipal ?recycling bin for batteries or a council dump where the debris can be disposed of safely. Be very careful not to inhale the dust form the broken bulb.

According to David Barry , founder Shorewood-based Smartwire, ?a safe alternatives to low-energy bulbs is using smart dimmers with dimmable L.E.D.

So the next time a low-energy bulb in your home breaks, do not do anything that could cause serious harm to your family and dispose of the poisonous debris properly to ensure your safety.

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Beauty Book for brain cancer ? Darren Tieste | Pop Couture

I wanted to share a lovely birthday present (from April) with you as its possibly the best coffee table book you?d ever grace your table with.

Its the Beauty Book for brain cancer, by renowned fashion and celebrity photographer Darren Tieste, who was drawn to put it together after the loss of a dear friend to the disease. ?So many celebrities stepped up to be involved in the project, and when I glance through the pages, I gasp and sigh at all the gorgeous shots. We?re talking Justin Timberlake, Leighton Meester, Amy Adams, Emily Blunt? I could go on! Just a few to share with you after the jump;

Was drawn to this lush green dress worn by Samantha Harris.

?

Flawless look on Eliza Dushku. Just, stunning.

Emily VanCamp here looking sultry, and like a 40?s style seductress here.

You can get yours through directly from the website here. All of the money raised from the book sales will go to not-for-profit charities to do with the research for brain cancer.

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Functional Analysis of a Breast Cancer-Associated Mutation in the Intracellular Domain of the Metalloprotease ADAM12

by Dorte Stautz, Ulla M. Wewer, Marie Kveiborg

A recently identified breast cancer-associated mutation in the metalloprotease ADAM12 alters a potential dileucine trafficking signal, which could affect protein processing and cellular localization. ADAM12 belongs to the group of A Disintegrin And Metalloproteases (ADAMs), which are typically membrane-associated proteins involved in ectodomain shedding, cell-adhesion, and signaling. ADAM12 as well as several members of the ADAM family are over-expressed in various cancers, correlating with disease stage. Three breast cancer-associated somatic mutations were previously identified in ADAM12, and two of these, one in the metalloprotease domain and another in the disintegrin domain, were investigated and found to result in protein misfolding, retention in the secretory pathway, and failure of zymogen maturation. The third mutation, p.L792F in the ADAM12 cytoplasmic tail, was not investigated, but is potentially significant given its location within a di-leucine motif, which is recognized as a potential cellular trafficking signal. The present study was motivated both by the potential relevance of this documented mutation to cancer, as well as for determining the role of the di-leucine motif in ADAM12 trafficking. Expression of ADAM12 p.L792F in mammalian cells demonstrated quantitatively similar expression levels and zymogen maturation as wild-type (WT) ADAM12, as well as comparable cellular localizations. A cell surface biotinylation assay demonstrated that cell surface levels of ADAM12 WT and ADAM12 p.L792F were similar and that internalization of the mutant occurred at the same rate and extent as for ADAM12 WT. Moreover, functional analysis revealed no differences in cell proliferation or ectodomain shedding of epidermal growth factor (EGF), a known ADAM12 substrate between WT and mutant ADAM12. These data suggest that the ADAM12 p.L792F mutation is unlikely to be a driver (cancer causing)-mutation in breast cancer.

For the full article visit:
Functional Analysis of a Breast Cancer-Associated Mutation in the Intracellular Domain of the Metalloprotease ADAM12
Syndicated from:PLoS ONE

Article is licensed under a Creative Commons Attribution License.

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Insight: U.S. hedge funds find ways to trade euro misery

BOSTON/NEW YORK (Reuters) - Two decades ago, George Soros rose to fame and fortune on his now-historic trade in which he took on the Bank of England and shrewdly wagered on a devaluation of the British pound.

But it's unlikely the current European monetary crisis and worries about Greece's potential exit from the euro zone will give rise to an investing legend like Soros, who made $1 billion in 1992 by betting on a decline in the price of the pound.

Instead, there are a multitude of strategies to play Europe's troubles, and many different participants, according to U.S. hedge fund managers.

"There is not room for one player to have such impact," said John Brynjolfsson, whose California-based Armored Wolf hedge fund has been betting against the euro for quite some time. "Financial markets are so much bigger today."

A spokesman for Soros, who last year converted his Soros Fund Management to a family office and stopped managing money for outside investors, could not be reached for comment.

Brynjolfsson and several other U.S. money managers who are trying to profit from Europe's misery say they expect the current crisis to produce a lot of winners.

So far this year, the euro is down 3.3 percent against the U.S. dollar.

U.S. money managers say it's hard to swing for the fences the way Soros did because institutional investors are far more squeamish about having too much money riding on any single trade. There is also heightened sensitivity from pensions and endowments to taking an investment strategy that might spark political outrage from European leaders.

Another thing working against the rise of a new Soros is that trading the euro zone, or even the fallout from a Greek exit, is a much more complicated than betting against a single currency.

Money managers are playing the euro zone crisis by trading currencies, wagering on the direction of bank stocks or using derivatives like credit default swaps to bet on potential corporate and bank failures. Greenlight Capital's David Einhorn recently said he is bullish on gold and gold miners, in part because of concern about the fallout from a euro zone meltdown.

Some managers are even going both short and long on different European sovereign debt, depending on their views of the financial stability of different countries.

Adam Fisher, manager of the $320 million Commonwealth Opportunity Capital hedge fund, noted that Soros faced a "single country, not 17 different countries, one decision maker, not 17."

Fisher's fund, which has more than 80 percent of its money invested in Europe, is taking a somewhat contrarian position by owning the European sovereign debt of Germany, the Netherlands, Italy and Spain.

Hedge fund managers point out that given the up-and-down nature of the euro zone crisis, most hedge funds have been in and out of trades or forced to adjust positions depending on the changing political winds.

Earlier this year, for instance, it looked like concern about Greece exiting the euro had passed. But with the recent results of the Greek election at odds with the austerity measures demanded by its currency partners, the risk of a Greek departure from the euro zone has risen dramatically.

Recently, Fisher said his Los Angeles-based fund had reduced the size of some of its more bullish sovereign debt trades because he believes there will be "violent" market swings this summer.

"It is going to be incredibly difficult to manage risk through that environment," said Fisher, whose fund was up 8.8 percent through April. "I don't think hedging will do anything. The way you hedge, is you sell. You don't subtract risk by adding risk."

Brynjolfsson, a former top portfolio manager for bond mutual fund firm Pacific Investment Management Co, is betting on Greece exiting the euro. He said it will be hard for European leaders to take the necessary steps to appease the Greek government without infuriating politicians in other euro zone countries.

"As the wheels began falling off the bus, we adjusted to have a short bias and that has worked out," said Brynjolfsson, whose $750 million hedge fund is up 2 percent this year, largely on its short bet against the euro.

Axel Merk, president and chief executive officer of Merk Investments, an investment advisory firm that specializes in currencies, said the growing problems with Greece and the euro zone led him recently to dump all the euros in his $517 million Merk Hard Currency Fund, which is up 2.29 percent for the year.

Merk now favors the Singapore dollar, which has climbed 1.34 percent since January.

Ray Dalio's $120 billion Bridgewater Associates gained 23 percent in 2011 in part because of profits made from a series of European bets, said a person familiar with the Westport, Conn.-based fund who declined to discuss specifics of the strategy. In a recent interview with Barron's, Dalio said European banks "are now over-leveraged and can't expand their balance sheets" and European nations "don't have enough buyers of their debt."

Dalio may be the U.S. money manager who comes closest to rivaling the Soros of two decades ago. His hedge fund is the industry's largest and he widely regarded as one of the most successful managers.

Among the ways funds are playing the European turmoil, some are betting against the fortunes of Spanish and Italian banks instead of simply focusing on sovereign debt.

John Paulson, among others, bets against European sovereign debt as way to hedge the overall portfolio of his Paulson & Co hedge fund firm.

Daniel Loeb's Third Point fund put on a long position in Portuguese sovereign bonds in the first quarter because the New York-based manager believed the nation is in better shape than others in the euro zone.

"Portugal's debt profile is more consistent with Italy's than Greece's, its banks are substantially healthier than Spain's, and its government has enacted more aggressive labor reforms and is more stable than regimes in both countries," Loeb wrote in a May 16 investors' letter seen by Reuters.

If nothing else, the European crisis is forcing managers to keep coming up with new strategies to trade. One might say it's almost become an incubator for hedge fund managers to stretch their investment acumen.

Merk said he might look again at Europe if the political and financial situation gets more clarity. But he would likely do it a bit differently.

"If there is clarity in the process again, then we will certainly look at Europe again," he said. "But not through Greek debt, but through German bills."

(Reporting By Svea Herbst-Bayliss and Katya Wachtel; edited by Matthew Goldstein, Jennifer Ablan, Martin Howell)

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38-cr golf course waits for CM

http://www.mid-day.com/news/2012/may/260512-mumbai-Rs-38-cr-golf-course-to-wait-9-months-for-CM-inauguration.htm

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The brand new 11-hole golf course in Kharghar, ready since February, will have to wait well until after the monsoon to be inaugurated, thanks to Cidco?s insistence that the CM do the honours. In the last four months, unavailability of dates from the chief minister has led Cidco officials to skip several occasions marked for the inauguration. Now, the problem is the model code of conduct imposed in Raigad prior to local body elections.


The hole truth: CIDCO has been spending Rs 10 lakh ?a month to maintain the course for the past 4 months

The code is in force till the end of this month. When that ends, the monsoon will play spoiler for the next three-four months. Officials say they will need a month thereafter to trim the lawn. As such, November is the month tentatively scheduled for the opening. As per Cidco?s targets, the golf course was supposed to rake in over Rs 1 crore in six months through commercial use by the public and international matches. But as long as it lies unused, the target will not be met.


Bogey! The golf course was supposed to make Rs 1 crore in 6 months through commercial usage, but instead of the profits, CIDCO has only been accruing monthly maintenance expenses of Rs 10 lakh

?We had plans of making over Rs 1 crore in six months from the course, where people will be allowed to play golf at nominal cost. We are likely to lose this income now as the unveiling is not likely to happen before November,? said a senior Cidco official requesting anonymity. More concrete losses have accrued to Cidco in the form of monthly maintenance expenses of around Rs 10 lakh for the past four months.

?We completed the construction in February and have since been incurring expenses of around Rs 10 lakh every month for maintenance of the course. If the inauguration does not happen in the next few days, grass will grow rank on the course due to the rains. We will then have to chop it, level the course using earthmoving machines, and do much more,? said Ramesh Giri, executive engineer, Cidco.

Cidco is still sticking firm to its decision of getting the CM for the inauguration. Mohan Ninawe, public relations officer, Cidco, said, ?Due to the code of conduct in Raigad, we are not able to get the CM for the inauguration. We will seek his availability once the code of conduct gets over. The opening ceremony will only be at the hands of the CM, and it is very difficult to say when that will be possible. Until then, the course will not be made operational.?

Long overdue
The work on the golf course in Kharghar started in January 2008 and was supposed to be completed by February 2010. But delay in getting clearances cost the City and Industrial Development Corporation of Maharashtra Ltd (Cidco) two more years to complete the course. The body has attempted to get the CM for its inauguration at least three times till now. Officially, the ceremony was announced for March 24, then April 26, but was cancelled both times. Initially, the course was supposed to be constructed with 18 holes at a cost of Rs 52 crore. But Cidco did not get permission from the forest department for using its land to construct seven holes, and went on to build an 11-hole course at Rs 38 crore.

Voices
I have been waiting for the golf course for the last few years, as we do not have a single one in Navi Mumbai. Why are the authorities not throwing it open even though it was developed four months ago?
--- Vishwajit Desai, engineer at shipping company

Cidco should not wait for the CM for the inauguration, as that means the course will remain unused for another four months after the monsoon sets in. The inauguration can be done after opening of the golf course.
-- Yugesh Ganeshe, nutrition officer with a private company

It is ridiculous to put on hold the opening of the golf course for such a trivial reason. Cidco should throw it open to the public without any formality as it is constructed with people?s money.
-- Ashish Indapawar, IT professional ?

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California Supreme Court Rejects Calls From Law Enforcement To Review Dispensary Case

gavel cannabisPeople v. Colvin Affirms That Dispensing Collective Members Are Not Required To Help Cultivate Their Medication

In a major victory for medical marijuana patients, the California Supreme Court denied review yesterday of an important dispensary case out of Los Angeles. Rejecting calls from State Attorney General Kamala Harris and law enforcement to review the Court of Appeal ruling in People v. Colvin, the California Supreme Court upheld certain protections for medical marijuana patients and providers. The Attorney General had argued that some undefined percentage of patients were legally required to participate in the operation of the medical marijuana dispensaries in order to obtain medication from them.

The landmark ruling in Colvin held that the Attorney General?s argument that member-patients must engage in unspecified ?united action or participation? to qualify for protection under the state?s medical marijuana law would likely ?limit drastically the size of medical marijuana establishments,? and provide ?little direction or guidance to, among others, qualified patients, primary caregivers, law enforcement, and trial courts.? Furthermore, the Colvin Court held that the Attorney General?s requirement would ?contravene the intent of [state law] by limiting patients? access to medical marijuana.?

The Court of Appeal also held in People v. Colvin that, ?collectives and cooperatives may cultivate and transport marijuana in aggregate amounts tied to its membership numbers.? In addition, the Colvin decision affirmed that possession of extracted or concentrated forms of medical marijuana was legal under state law.

?The decision not to review People v. Colvin should now put to rest this unfounded notion that patients must ?till the soil? or somehow participate in the production of the medicine they purchase at a dispensary,? said Joe Elford, Chief Counsel with Americans for Safe Access (ASA), the country?s leading medical marijuana advocacy organization. ?This landmark case also affirms the right of patients to purchase extracted or concentrated forms of medical marijuana and the right to transport medication from an off-site cultivate site.?

A number of medical marijuana dispensary cases were granted review by the California Supreme Court earlier this year, including Pack v. City of Long Beach, Riverside v. Inland Empire Patient?s Health and Wellness Center, and City of Lake Forest v. Evergreen Holistic Collective. The Pack case addresses issues of federal preemption, which have already come before the High Court, whereas the Riverside and Lake Forest cases address the issue of whether localities have a right to permanently ban dispensaries.

?The Colvin decision has far-reaching, positive implications for medical marijuana patients and providers,? continued Elford. ASA is currently appealing the conviction of Jovan Jackson, a San Diego dispensary operator who was tried in September 2010 and denied a medical marijuana defense. ?The Colvin decision is bad news for the Attorney General, who was relying on the same argument in the Jackson case.? There are also other trial court cases that will invariably be affected by the Supreme Court?s decision not to review the Colvin case.

Further information:

Landmark Court of Appeal decision in People v. Colvin: http://AmericansForSafeAccess.org/downloads/People_v_Colvin.pdf

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